|
|
Stress-strain analysis of mandible with applied fixator due to the missing bone tissue
Fňukal, Jan ; Valášek, Jiří (referee) ; Marcián, Petr (advisor)
This thesis deals with the fixation of lower jaw with bone tissue defect using commercially produced fixator. Large defects of bone tissue are mainly caused due to the removal of bone tissue affected by tumor. These topics have been researched on the basis of the literature. Subsequently, stress strain analysis of the lower jaw with the applied fixation plate was performed. This analysis was solved by using computational modeling with variational approach, ie the finite element method. The work also describes in detail the procedure of creating model of geometry, model of material, model of boundary conditions and loads with subsequent solution of several computational models. The stress strain analysis was done for lower jaw with varying size of the removed bone tissue with applied reconstruction plate made of CP-Ti Grade 4 and for the lower jaw with the plate, which is made of -Ti-Mo. Finally, the influence of the mechanical properties of the callus during formation of new bone tissue (callus healing) on the stress and deformation of the solved system was evaluated.
|
|
|
Stress - strain analysis of jaw with tooth implant type BOI
Marcián, Petr ; Fuis, Vladimír (referee) ; Florian, Zdeněk (advisor)
Submitted master thesis deals with stress - strain analysis of jaw, with dental implant. The implant serve as a suitable pillar for crown or dental bridge, when one or more teeth are lost. The project is oriented on BOI (basale - oseo - integrable) dental implant type, which is produced by DENTALIHDE company. Stress – strain condition of the mandible system with implant have been established by computational simulation, with use of the final elements method. Important part of down jowl is simulated on with EDS and EDDS applied types of implants. After implementation the implant begins to heal. Therefore the special attention is paid to stress - strain states on various level of osteointegration. There is a detail description of production of single part computational model and his solving in the master thesis. Presentation of large chapter with results and subsequent alteration stress - strain analysis is part of the master thesis. Program SolidWorks 2005 was used to create the geometric model. Computational model and the actual solving was accomplished with use of ANSYS 11.0 and ANSYS Wor-kbench systems.
|
|
|
Stress - strain analysis of jaw with tooth implant type MTI
Petrlíková, Helena ; Fuis, Vladimír (referee) ; Florian, Zdeněk (advisor)
This diploma work is oriented on the deformation and load stress analysis of the jawbone with the razor-blade dental implant of the company MTI. There is a literature search on this theme in the beginning of this work. Deformation and tenseness of the system is done by computerized method FEM. There is detailed description of creating the computational model in this work. The geometry model of the system was created in the 3D CAD design software SolidWorks. Discretization, model of constrains and load sets including own solution was created in the ANSYS Workbench. On the basis of solutions with different load sets, which are presented in this work, is created a deformation and load stress analysis for two razorblade implant of copany MTI.
|
|
|
Role of transcription factors MEIS in the origin and development of the neural crest
Fábik, Jaroslav
Unique to the vertebrate embryo, neural crest cells represent a multipotent cell population that migrates throughout the body and gives rise to a multitude of different types of cells and tissues. Cranial neural crest cells populate the developing pharyngeal arches and establish skeletogenic condensations that generate the future bones and cartilages of the face and neck. Moreover, these cells send out and receive signals from adjacent tissues of non-neural crest origin, such as the mandibular epithelium and muscle precursor cells. Such reciprocal interactions give rise to organs and structures, for instance, to the tongue. The aim of this work was to elucidate the roles of homeodomain-containing MEIS transcription factors in neural crest cells and in craniofacial development, by using a mouse model with conditional inactivation of Meis2 gene in neural crest cells. We show that transcription factor MEIS2 is expressed in the medial region of the developing mandible and in the developing tongue. Conditional Meis2 inactivation using the Wnt1-Cre2 mouse strain caused mandible and tongue hypoplasia, and ectopic bone formation at the expense of tongue development. These mandibular arch anomalies were accompanied by the loss of Hedgehog signaling in the mandibular epithelium, expanded RUNX2 expression in...
|
|
|
Role of transcription factors MEIS in the origin and development of the neural crest
Fábik, Jaroslav ; Machoň, Ondřej (advisor) ; Buchtová, Marcela (referee) ; Procházka, Jan (referee)
Unique to the vertebrate embryo, neural crest cells represent a multipotent cell population that migrates throughout the body and gives rise to a multitude of different types of cells and tissues. Cranial neural crest cells populate the developing pharyngeal arches and establish skeletogenic condensations that generate the future bones and cartilages of the face and neck. Moreover, these cells send out and receive signals from adjacent tissues of non-neural crest origin, such as the mandibular epithelium and muscle precursor cells. Such reciprocal interactions give rise to organs and structures, for instance, to the tongue. The aim of this work was to elucidate the roles of homeodomain-containing MEIS transcription factors in neural crest cells and in craniofacial development, by using a mouse model with conditional inactivation of Meis2 gene in neural crest cells. We show that transcription factor MEIS2 is expressed in the medial region of the developing mandible and in the developing tongue. Conditional Meis2 inactivation using the Wnt1-Cre2 mouse strain caused mandible and tongue hypoplasia, and ectopic bone formation at the expense of tongue development. These mandibular arch anomalies were accompanied by the loss of Hedgehog signaling in the mandibular epithelium, expanded RUNX2 expression in...
|
|
|
Evaluation of ontogenetic development of the mandible using geometric morphometric methods
Kiebelová, Alena ; Velemínská, Jana (advisor) ; Brůžek, Jaroslav (referee)
During ontogeny there are a lot of changes in the entire human skeleton. This thesis deals with shape changes in the mandible, which are caused by genetic, hormonal, as well as mechanical factors. The most important mechanical factors influencing the shape of mandible are development of deciduous and permanent dentition and also development of masticatory muscles. 34 children mandibles of known age and 14 adult mandibles were analysed and compared for this thesis. Data were obtained by scanning coordinates of 36 landmarks using Microscribe G2X, and then were processed by software PAST and Morphologika2 using multivariate statistics (PCA, MANOVA). Geometric morphometrics is used for a detailed analysis of shape changes of the mandible. There is no difference between dental and chronological age. In conclusion, lower jaw narrows during growth, the body extends more in the region of third molars and the ramus grows mainly in the region of condylar process. Chin prominence also occurs during ontogeny. In the group of adult mandibles the variability is caused by coronoid process height and the body width. The hypothesis, that age groups are significantly different from each other, and therefore due to tooth mineralization there are marked shape changes, is confirmed.
|
|
|
Stress - strain analysis of jaw with tooth implant type MTI
Petrlíková, Helena ; Fuis, Vladimír (referee) ; Florian, Zdeněk (advisor)
This diploma work is oriented on the deformation and load stress analysis of the jawbone with the razor-blade dental implant of the company MTI. There is a literature search on this theme in the beginning of this work. Deformation and tenseness of the system is done by computerized method FEM. There is detailed description of creating the computational model in this work. The geometry model of the system was created in the 3D CAD design software SolidWorks. Discretization, model of constrains and load sets including own solution was created in the ANSYS Workbench. On the basis of solutions with different load sets, which are presented in this work, is created a deformation and load stress analysis for two razorblade implant of copany MTI.
|
|
|
Stress - strain analysis of jaw with tooth implant type BOI
Marcián, Petr ; Fuis, Vladimír (referee) ; Florian, Zdeněk (advisor)
Submitted master thesis deals with stress - strain analysis of jaw, with dental implant. The implant serve as a suitable pillar for crown or dental bridge, when one or more teeth are lost. The project is oriented on BOI (basale - oseo - integrable) dental implant type, which is produced by DENTALIHDE company. Stress – strain condition of the mandible system with implant have been established by computational simulation, with use of the final elements method. Important part of down jowl is simulated on with EDS and EDDS applied types of implants. After implementation the implant begins to heal. Therefore the special attention is paid to stress - strain states on various level of osteointegration. There is a detail description of production of single part computational model and his solving in the master thesis. Presentation of large chapter with results and subsequent alteration stress - strain analysis is part of the master thesis. Program SolidWorks 2005 was used to create the geometric model. Computational model and the actual solving was accomplished with use of ANSYS 11.0 and ANSYS Wor-kbench systems.
|
|
|
Stress-strain analysis of mandible with applied fixator due to the missing bone tissue
Fňukal, Jan ; Valášek, Jiří (referee) ; Marcián, Petr (advisor)
This thesis deals with the fixation of lower jaw with bone tissue defect using commercially produced fixator. Large defects of bone tissue are mainly caused due to the removal of bone tissue affected by tumor. These topics have been researched on the basis of the literature. Subsequently, stress strain analysis of the lower jaw with the applied fixation plate was performed. This analysis was solved by using computational modeling with variational approach, ie the finite element method. The work also describes in detail the procedure of creating model of geometry, model of material, model of boundary conditions and loads with subsequent solution of several computational models. The stress strain analysis was done for lower jaw with varying size of the removed bone tissue with applied reconstruction plate made of CP-Ti Grade 4 and for the lower jaw with the plate, which is made of -Ti-Mo. Finally, the influence of the mechanical properties of the callus during formation of new bone tissue (callus healing) on the stress and deformation of the solved system was evaluated.
|
|
|
Evaluation of ontogenetic development of the mandible using geometric morphometric methods
Kiebelová, Alena ; Velemínská, Jana (advisor) ; Brůžek, Jaroslav (referee)
During ontogeny there are a lot of changes in the entire human skeleton. This thesis deals with shape changes in the mandible, which are caused by genetic, hormonal, as well as mechanical factors. The most important mechanical factors influencing the shape of mandible are development of deciduous and permanent dentition and also development of masticatory muscles. 34 children mandibles of known age and 14 adult mandibles were analysed and compared for this thesis. Data were obtained by scanning coordinates of 36 landmarks using Microscribe G2X, and then were processed by software PAST and Morphologika2 using multivariate statistics (PCA, MANOVA). Geometric morphometrics is used for a detailed analysis of shape changes of the mandible. There is no difference between dental and chronological age. In conclusion, lower jaw narrows during growth, the body extends more in the region of third molars and the ramus grows mainly in the region of condylar process. Chin prominence also occurs during ontogeny. In the group of adult mandibles the variability is caused by coronoid process height and the body width. The hypothesis, that age groups are significantly different from each other, and therefore due to tooth mineralization there are marked shape changes, is confirmed.
|
guest ::
